Mechanism that controls reactivation of neural stem cells discovered
Oct 18, 2024 · Dr Gao Yang, the study’s first author and a research fellow with Duke-NUS’ Neuroscience and Behavioural Disorders Programme, explained: “We have demonstrated for the first time that the SUMO protein family plays a pivotal role in neural stem cell reactivation and overall brain development.
Novel nasal spray effectively prevents influenza infection
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Immuno-oncology innovations redefining cancer treatment in 2024
Jan 23, 2024 · Dr Espen Basmo Ellingsen. University of Oslo . Dr Ellingsen is a Medical Doctor and holds a PhD in cancer immunology from the University of Oslo. Background in translational research from the Institute for Cancer Research at Oslo University Hospital, focusing on therapeutic cancer vaccination, induced immune responses, and their impact on the tumor microenvironment.
How AI will reshape pharma in 2025 - drugtargetreview.com
Dec 20, 2024 · Artificial intelligence (AI) has revolutionised many industries, yet its adoption in pharmaceutical drug development has been notably slower. Concerns surrounding data security, the complexity of AI systems, and the rigorous regulatory frameworks in this field have caused the pharmaceutical industry to approach these technologies with caution.
Developing an effective vaccine for herpes simplex virus
Feb 13, 2024 · Co-corresponding author Dr David Leib, chair and professor of microbiology and immunology at Geisel, explained: “Despite three decades of trying, the scientific community has been unable to develop an effective vaccine against herpes, and I think the main issue has been that we haven’t fully understood what we need, in terms of antibodies and their specific functions, to protect against ...
Overcoming obstacles in personalised medicine
Dec 11, 2024 · Seth Lederman is a physician, scientist and entrepreneur, and a co-founder of Tonix Pharmaceuticals. Prior to Tonix, Dr Lederman founded Targent Pharmaceuticals, which developed late-stage oncology drugs, including levoleucovorin.
Exploring the potential of ADCs beyond oncology - Drug Target …
Aug 6, 2024 · Antibody Drug Conjugates (ADCs) are already deployed as part of the roster of oncology treatments, but here, Mike Ward, Head of Thought Leadership for Life Sciences & Healthcare, Clarivate, looks into their potential to help treat a whole range of other diseases and conditions. He discusses the barriers and enablers that will impact ADCs’ ability to make the shift from oncology to a broader ...
Enhancing gene therapy with Circio - Drug Target Review
May 22, 2024 · In this Q&A, Erik Wiklund, CEO of Circio, explains the key findings of their circVec circular RNA platform technology, why they chose AAV-based gene therapy for AATD as the lead programme, and their plans for the future to enhance the potency and reduce the cost of current gold-standard gene therapy.
Brain organoids: a fascinating and powerful tool for drug discovery
Jul 5, 2024 · Building three-dimensional models in the lab. Brain organoids are three-dimensional (3D) multicellular structures derived from the differentiation of human pluripotent stem cells (hPSCs), including induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs), under specific in vitro neuronal induction conditions, using specific support matrices.
The art and science of drug formulation - Drug Target Review
Aug 9, 2024 · Drug formulation is a cornerstone of modern medicine, turning raw active ingredients into consumable, effective therapies. This critical phase in drug development ensures that medications are safe, effective, and user-friendly.