Recently identified as a polar granule component, PIWI proteins appear to control germ cell formation so much so that in the absence of PIWI proteins there is a significant decrease in germ cell formation.

PIWI proteins play crucial roles during germline development and gametogenesis of many metazoan species, from germline determination and germline stem cell maintenance to meiosis, …

Sep 14, 2022 · PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs that associate with proteins of the PIWI clade of the Argonaute family. First identified in animal germ line cells, …

Apr 29, 2025 · PIWI-interacting RNAs (piRNAs) are a distinct class of small non-coding RNAs, typically ranging from 24 to 31 nucleotides in length. This size range sets them apart from microRNAs …

Nov 29, 2023 · The association of abnormally dysregulated piRNAs/PIWI proteins with human diseases can be broadly divided into two categories. On the one hand, the blue background of piRNA/PIWI …

Piwi-interacting RNAs (piRNAs) are a class of small non-coding RNAs, approximately 24–32 nucleotides in length, primarily expressed in germline cells, that play crucial roles in gene silencing, genome …

Piwi-interacting RNA (piRNA) is the largest class of small non-coding RNA molecules expressed in animal cells. [1][2][3] piRNAs form RNA- protein complexes through interactions with piwi -subfamily …

Inspired by a recent workshop on PIWI proteins and piRNAs, this commentary aims to summar-ize fundamental aspects of piRNA biology, highlight recent advances, and discuss key outstanding …

Jan 15, 2025 · Here we demonstrate that after target binding, PIWI proteins undergo a conformational change from an ‘open’ state to a ‘locked’ state, facilitating base pairing and enhancing target cleavage...

PIWI proteins and piRNAs are mostly known for their role in transposon silencing during animal germ cell development. piRNAs are small non-coding RNAs that require PIWI proteins for their biogenesis …