Oct 31, 2018 · With the formation of a core–shell HA-AuNPs@SiNPs nanoprobe by self-assembly, the fluorescence of SiNPs could be quenched by HA-AuNPs through fluorescence resonance energy transfer (FRET). The addition of hyaluronidase leads to cleavage of HA into small fragments, and SiNPs are released.

In this paper, a novel composite nano diagnostic and therapeutic agent HA-AuNPs/FDF was constructed for highly sensitive fluorescence detection of hyaluronidase (HAase), tumor-targeting fluorescence cell imaging and photodynamic/photothermal synergistic therapy.

Jun 1, 2023 · MTT assay and hemolysis tests confirmed the good cyto- and hemo-compatibility of nanoprobe. A highly sensitive nanoprobe HAPPF@FeSe 2 NPs was developed for real-time detection of hyaluronidase (HAase) as tumor marker. Hyaluronic acid (HA) was first functionalized with adipic acid dihydrazide (ADH) via amide formation.

Jul 28, 2014 · In this study, a novel ratiometric fluorescent sensing system based on both aggregation-induced emission (AIE) and aggregation-induced quenching (ACQ) was developed to quantitatively assess hyaluronidase level.

Feb 7, 2020 · Herein, a hyaluronic acid (HA) hydrogel based on the fluorescence resonance energy transfer (FRET) effect was constructed for the detection of HAase. FITC and AuNPs were covalently coupled with two HA derivatives respectively to form a fluorescent donor-acceptor pair.

Feb 9, 2022 · To overcome this limitation, we introduced hyaluronic acid-modified gold nanoparticles (HA-AuNPs) into a muscle bundle-based biohybrid robot that moves forward in response to electrical stimulation. To enhance the actuation of muscle bundles, HA-AuNPs were embedded into the muscle bundles.

Jan 1, 2023 · Herein, a hyaluronic acid (HA) hydrogel based on the fluorescence resonance energy transfer (FRET) effect was constructed for the detection of HAase. FITC and AuNPs were covalently coupled with...

The camptothecin (CPT)-loaded HA-SS-BFVPBT nanoparticles (HSBNPs) are developed as a multifunctional platform for two-photon imaging and synergistic chemo-photodynamic therapy at the same time, offering a promising new avenue for imaging-guided efficient cancer therapy.

Dec 1, 2014 · In this study, we report the one-step facile synthesis of fluorescein isothiocyanate-labeled hyaluronic acid (FITC–HA) functionalized fluorescent AuNPs based FRET nanoprobes (FITC–HA–AuNPs) via chemical reduction of HAuCl 4 by using FITC–HA as both a reducing and stabilizing agent.

Mar 27, 2024 · In this study, we described a novel fluorescence method for sensitive, rapid, and convenient HAase detection and tumor-targeting drug delivery and imaging, using a probe prepared by electrostatic assembly of a cationic conjugated polymer (CCP) and anionic hyaluronan (HA) conjugated with the anticancer drug doxorubicin (Dox).