Targeted rewriting of the epigenome promises to overcome several challenges in direct gene editing in patient therapies.

Researchers from the National University of Singapore (NUS) have revealed that diet and exercise can change gene regulation ...

Others fine-tuned gene expression in specific biological contexts. But a few coordinated widespread transcriptional programs, including master regulators Cyc8, Rap1, and Abf1 that influenced over a ...

Supported by 32 network correlations with gene expression relevant to transcriptional regulation, endocrine disruption, lipid homeostasis, and inflammation, our findings suggest that complex ...

This manuscript describes an important finding of the transcriptional control of a chimeric gene transfer agents (GTA) cluster in Bartonella by a processive anti-termination factor (BrrG). The ...

Abstract The three-dimensional (3D) chromatin structure of Epstein–Barr virus (EBV) within host cells and the underlying mechanisms of chromatin interaction and gene regulation, particularly those ...

Discussion The regulation of EPO expression, a key hormone in erythropoiesis, has been studied for decades, but its complex regulatory mechanisms remain elusive.

Through the citrullination of histones, these enzymes facilitate chromatin relaxation, enabling access for RNA polymerase II and transcriptional machinery to initiate gene expression.

Single-cell RNA sequencing and computational analysis define a spatial and temporal map of gene expression during early patterning and morphogenesis of the mouse cranial neural plate, providing a ...

Significance Many transcriptional and post-transcriptional mechanisms control gene expression in eukaryotic cells. The zinc finger antiviral protein (ZAP) is induced by interferon and inhibits viral ...