A new research paper was published on the cover of Aging's Volume 16, Issue 4, entitled, “Mapping the core senescence phenotype of primary human colon fibroblasts.” ...

For years, scientists have known that aging begins in the smallest units of life: cells. But what turns this cellular decline ...

When cells age and stop dividing, that’s called cellular senescence. In the short term, senescence protects against DNA damage and tumor formation. Then the immune system eliminates the senescent ...

Figure 1. WEW decreases cellular senescence in human fibroblasts and cancer cells. Electrolyzed-reduced water has powerful antioxidant properties with constituents that scavenge reactive oxygen ...

Methodology Researchers at Osaka University conducted the study using primary human foreskin fibroblasts (HFF-1 cells), which were cultured and passaged repeatedly to induce replicative senescence.

Senescence was induced in normal colon fibroblasts isolated from colorectal rectal cancer patients resected from normal adjacent tissue. Senescence associated secretory phenotype (SASP) factors were ...

In this study, using budding yeast and normal human fibroblasts, we found that cellular senescence—stable cell cycle arrest contributing to organismal aging—is the long-term outcome of PMD.” ...

Senescent skin cells, often referred to as zombie cells because they have outlived their usefulness without ever quite dying, have existed in the human body as a seeming paradox, causing inflammation ...

nouement: suicide or cancer.© 2005 Elsevier Science Exogenous expression of the ras oncogene triggers senescence in human fibroblasts. Staining with DAPI reveals the gradual appearance of ...

Replicative senescence is associated with telomere shortening and the loss from the ends of chromosomes of about 100 bp per population doubling. In March 19 Science, Jan Karlseder and colleagues at ...