Subcellular lipid composition and transport significantly influence the physiological and pathological functions of both ...

Dampening the integrated stress response (IRS) in motor neurons may be a valid therapeutic approach in patients with an inherited form of ALS.

Recent research highlights concerns about maltodextrin, a common food additive, and its potential to disrupt gut health.

Sec61 is a critical component of the protein translocation machinery that mediates the entry of most secreted and transmembrane proteins into the endoplasmic reticulum. Sec61 has been proposed as a ...

Endoplasmic reticulum oxidoreductase 1 (ERO1) has traditionally been associated with proper protein folding in the endoplasmic reticulum, but it has recently been linked to platelet activation and ...

Coronary artery disease is characterized by chronic immune‐inflammation, excessive endoplasmic reticulum (ER) stress, and platelet hyperactivity; however, whether there is a signaling hub linking ...

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The endoplasmic reticulum (ER) has a sophisticated quality control (QC) system to eliminate improperly folded proteins from the secretory pathway. Given that protein folding is such a fastidious ...

We aimed to clarify whether metabolic conjugates of sulfated and glucuronidated forms have the physiological potential to produce the vasorelaxant nitric oxide (NO) in human umbilical vein endothelial ...

The peripheral endoplasmic reticulum (ER) forms a continuous, dynamic network of tubules that plays an important role in protein transport and quality control, cellular signaling, and stress response.

Mechanistically, CPI-613 induces endoplasmic reticulum (ER) stress and triggers the expression level of XBP1s, which transcriptionally suppresses the expression of THBS2 gene. In addition, THBS2 ...