More than 44% of individuals receiving high doses of prolonged glucocorticoid medication develop osteonecrosis, with the femoral head being the most ...

Researchers have systematically mapped the complex cellular pathways leading to glucocorticoid-induced osteonecrosis of the ...

Cataracts are a leading cause of vision loss worldwide, and fibrosis-related complications after surgery often limit full ...

The FAS cell surface death receptor, a member of the tumor necrosis factor receptor family, activates both apoptotic and non-apoptotic signaling upon interaction with its ligand FASL. It is critical ...

Extrinsic and intrinsic pathways of apoptotic cell death. The extrinsic pathway is initiated by activation of death receptors or via cytotoxic T cells resulting in cleavage of initiator procaspase ...

A chemotherapeutic approach to combat cancer involves focusing on apoptosis, a programmed cell death mechanism. (26) Key characteristics of apoptotic cell demise include nucleus fragmentation and ...

The molecular interaction of these signal pathways that initiates the loss of auditory HCs following acoustic trauma is covered and possible therapeutic interventions that may protect these sensory ...

Apoptotic cell death is an important feature of atherosclerotic plaques, and it seems to exert both beneficial and detrimental effects depending on the cell type and plaque stage. Because late ...