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The Detroit Lions lost for the first time since Sept. 15 in a high-scoring affair with the Buffalo Bills in Week 15 at Ford Field in Detroit in a matchup of two of the NFL's best teams.

The Buffalo Bills will look to improve to 11-3 when they face the Detroit Lions on Sunday. For the first time in weeks, the Bills may have a fully-healthy offense, as multiple weapons are set to ...

but he'll be available for Buffalo's regular-season finale. With the team locked into the No. 2 seed in the AFC, a number of the Bills' key skill players could have their workloads managed ...

A month ago, I was surprised when the Buffalo Bills didn't jump to No. 1 after beating the previously undefeated Kansas City Chiefs. But after beating the reigning Super Bowl champs decisively at ...

ORCHARD PARK - This is fun, right, Buffalo Bills fans? After two decades of New England not only dominating the Bills with Tom Brady at quarterback and Bill Belichick fashioning his array of ...

The New England Patriots and Buffalo Bills play on Sunday, Dec. 22 at Buffalo's Highmark Stadium in a game on the NFL Week 16 schedule. Which team will win the NFL Week 16 game? Check out these ...

We have a possible Super Bowl matchup coming in Week 15 with the Buffalo Bills (10-3) visiting the Detroit Lions (12-1) in a heavyweight matchup. Josh Allen pretty much did it all for Buffalo when ...

On paper, the matchup between the New England Patriots (3-11) and the Buffalo Bills (11-3) shouldn't be close. But this is the NFL, and anything can happen on Sundays. The losing streak in New ...

As of now the Buffalo Bills have the third-best odds in the league to win the Super Bowl, listed at +650. In their most recent game, the Bills took down the New York Jets 40-14. Josh Allen threw ...

But winning 12 straight, as the Lions could do on Sunday with a victory over the Buffalo Bills at Ford Field (4:25 p.m., CBS)? That’s elite territory — just 13 teams in the Super Bowl era (aka ...