The Arizona Cardinals close out the season in Week 18 at home facing the San Francisco 49ers for the second time. The Cardinals won the first meeting in Week 5 in Santa Clara 24-23 on a last-minute field goal by kicker Chad Ryland,

The Arizona Cardinals face the San Francisco 49ers in Week 18 at State Farm Stadium to close out the season. They want to finish with a win. They are down to backup and fourth-string tackles, and Michael Carter will start at running back. But the 49ers will have Josh Dobbs at quarterback, a rookie at running back and a depleted offensive line.

See who's in and who's out for the Week 18 matchup between the Arizona Cardinals and San Francisco 49ers on January 5, 2025.