The next set of discoveries between the Neher and Sakmann labs arrived in a set of three: whole-cell, inside-out, and outside-out patch clamp recordings. Alain Marty, another postdoctoral researcher ...

View Full Profile. Learn about our Editorial Policies. “This whole-cell patch method is really the gold standard for looking at synaptic and other events that make a neuron compute,” says Ed Boyden, a ...

The technique, called whole-cell patch-clamp electrophysiology, measures changes in two types of neurons—pyramidal and GABAergic—as well as changes in how signaling molecules, called ...