The work entitled " Macrophages suppress cardiac reprogramming of fibroblasts in vivo via IFN-mediated intercellular self-stimulating circuit" was published on Protein & Cell (published on Mar. 26 ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and ...

When macrophages are actively fighting infections or responding to inflammation (as is the case with IBD), they activate a protein called hypoxia-inducible factor 1-alpha, or HIF-1α, to help them ...

The study investigates how the myocardial infarction (MI) microenvironment affects the reprogramming of cardiac fibroblasts (CFs) into cardiomyocytes (CMs), focusing on the role of macrophages and ...

Those animals were found to have increased macrophage density in the left ventricle and exhibited elevated levels of a factor called IL-10, which is known to contribute to fibroblast activation.

These white blood cells activate macrophages and connective-tissue-forming cells called fibroblasts, which fuel joint inflammation. Typical RA treatments target the rogue white blood cells.

The activated fibroblasts produced profibrotic cytokines, contributing to the pathogenesis of IPF. Thus, the data emphasize a critical role for lung macrophages in the development of lung fibrosis.

“The results suggest a potential mechanism, at the tissue level and involving macrophages, of how pulmonary fibrosis originates,” says the study’s first author Ying Xu, a PhD candidate in Zhao’s lab.