The laminin-411 protein is vital for the formation of the myelin membrane by oligodendrocytes, report researchers from Japan.

The laminin-411 protein is vital for the formation of the myelin membrane by oligodendrocytes, report researchers from Japan.

Barbara Bendlin University of Wisonsin; Posted: 27 Aug 2021 There have been several hints over the years that myelin and AD pathology are related. Braak and Braak made an early and key observation ...

He adds that having APOE4 isn’t known to affect myelin levels in adults without Alzheimer’s pathology, and to his knowledge, nobody has investigated that potential. Therefore, the findings of reduced ...

One way axonal function may be hindered is through damage to the myelin sheath, a fatty coating that wraps around axons. Similar to the plastic or rubber used to insulate a cable, ...

Myelin degeneration increases with age, contributing to declining cognitive function in aged mice and suggesting altered myelin dynamics may at least partially underlie AD cognitive deficits. Moreover ...

Leukodystrophies are characterized by primary glial cell and myelin sheath pathology of variable aetiology; secondary axonal pathology can emerge as the disease progresses.

The myelin sheath surrounding the axons, or nerve fibers, can be compared to the insulation covering an electric wire. Without it, the rapid propagation of electric signals would not be possible.

Not all multiple sclerosis-like diseases are alike Date: May 19, 2020 Source: Tohoku University Summary: Scientists say some myelin-damaging disorders have a distinctive pathology that groups them ...

In Alzheimer's Disease, Myelin May Protect Against Tau Pathology - Medscape - Mar 16, 2022. Authors and Disclosures. Authors and Disclosures Author(s) Marisa DeNoble Loeffler, MS, for Medscape.

Brain injuries can also cause damage to myelin. Finding a way to help the sheath to repair itself could open the door to game-changing treatments for these conditions.

Now, researchers from the University of California San Francisco have identified an over-the-counter antihistamine called clemastine that can reverse damage to the myelin sheath and, what’s more ...