Thank you for your article on antisense 1 and for letting us know that the subject is very much alive. Although antisense is an "RNA therapeutic" in that the target is mRNA, actually in almost all ...

A new article in the peer-reviewed journal Nucleic Acid Therapeutics describes the characterization of antibodies targeting ...

Theoretically, PNAs can bind more strongly than most antisense drugs being developed today, which are snippets of DNA or RNA. But realizing that application was far from straightforward.

Much of the non-coding RNA is produced as the complementary strand to mRNA and is therefore referred to as antisense RNA (asRNA). Their function has been unclear for a long time.

The team, led by Heike Krebber, Dr. rer. nat., reported that double-stranded RNA (dsRNA)—that is, antisense RNA (asRNA) annealed to messenger RNA (mRNA)—is preferentially exported from the ...

Patients receiving a kidney transplant and who are positive for BK virus (BKV) are at risk of losing their transplant due to BKV reactivation. At this time, there are no antiviral options available ...

When LINE-1 RNA was depleted in human progeroid cells using antisense oligonucleotides the senescent phenotypes were ameliorated, while in the premature aging mouse model this therapy restored tissue ...

Though it is a linchpin of every living thing on Earth, RNA was misunderstood and underappreciated for decades — often dismissed as nothing more than a biochemical backup singer, slaving away in ...

They investigated the effects of antisense oligonucleotides targeting the regulatory RIα subunit of cAMP-dependent protein kinase (PKA). They treated human PC3 prostate cancer cells with antisense ...