The research team demonstrated that the inositol polyphosphate multikinase (IPMK) enzyme, a key player in the inositol metabolism system, acts as a critical transcriptional activator within the core ...

This study provides a vital mechanism proving that IPMK, a key enzyme in the inositol metabolism system, is a major transcriptional activator in the core gene expression network of animal cells.

Through the citrullination of histones, these enzymes facilitate chromatin relaxation, enabling access for RNA polymerase II and transcriptional machinery to initiate gene expression.

BUILDING A BETTER MODEL:Metabolic and regulatory networks may be expanded by coupling high-throughput phenotyping and gene expression data with the predictions of a computational model. (Reprinted ...

Gene expression regulation in cancer and cellular functions. ScienceDaily . Retrieved July 12, 2025 from www.sciencedaily.com / releases / 2025 / 01 / 250124151353.htm ...