Liposome extravasation into the tumor interstitium is a random event and, therefore, long liposome circulation times would increase accumulation within the tumor. Extravasation depends on the ...

These properties are favorable for extravasation of NM via diffusion and convection (due to transvascular fluid flow) in tumors, and enable passive tumor targeting using larger NM (e.g., 100 nm).

tumor cell extravasation/growth, and promoting chemotherapy resistance. Brain metastasis remains the most devastating and feared consequence of cancer with more than 40 percent of all cancer patients ...