The enzyme glutamine synthetase (GS) has a central role in cellular nitrogen metabolism. By carrying out the ATP-dependent formation of glutamine from ammonia and glutamate, GS detoxifies ammonia and ...

Tissue localizations of cytosolic glutamine synthetase (GS1; EC 6.3.1.2), chloroplastic GS (GS2), and ferredoxin-dependent glutamate synthase (Fd-GOGAT; EC 1.4.7.1) in rice (Oryza sativa L.) leaf ...

However, because glutamine synthetase is found throughout the body, its removal is lethal. “In our genetic studies, we rarely see patients with glutamine synthetase gene mutations,” Ni explained.

By analysing the effects genetic variants had on brain cells, they found the cause of a new rare condition – Glutamine Synthetase Stabilization Disorder – which causes seizures and delayed ...

More information: Xiaoyun Li et al, Tumor-instructed glutamine synthesis in cancer-associated fibroblasts promotes pro-tumor macrophages, Journal of Experimental Medicine (2025).