Cancer cells are more dependent on a cellular garbage disposal unit -- the proteasome -- than healthy cells, and cancer therapies take advantage of this dependency. Scientists have determined the ...

Structure of hRpn13 at the proteasome The C-terminal 38 amino acids of hRpn2 are sufficient for interaction with hRpn13 (refs 17, 47, 48). To further define the hRpn13-binding region in hRpn2, we ...

Image caption: Ribbon diagram (top right) showing seven-fold symmetry in the top view of the cylindrical TB proteasome, as revealed by x-ray crystallography.

Furthermore, complete proteasome dysfunction activates NRF1-mediated aggrephagy, inducing the expression of the aggrephagy-related genes p62 and GABARAPL1 (right).

A new study was conducted to understand the biochemistry and structure of a protein-cleaving complex (proteasome) that is essential to the TB bacterium’s survival. The findings were published in ...

Background: NPI-0052 is a second-generation proteasome inhibitor that has a novel structure with preclinical studies suggesting unique proteasome inhibition (PI), signal transduction, efficacy and ...