Rapid and extensive Schwann cell death under high-glucose pyruvate-depleted conditions can be evoked by the following sequential metabolic alterations; 1) diminished TCA cycle intermediates and ...

In this comprehensive analysis, the role of ING5 in lung cancer cell metabolism was investigated through a series of experiments, including phospho-proteomics, Western blot, and various cellular ...

Journal reference: Petrelli, F., et al. (2023) Mitochondrial pyruvate metabolism regulates the activation of quiescent adult neural stem cells. Science Advances. doi.org/10.1126/sciadv.add5220.

Agios Pharmaceuticals, Inc. (Nasdaq: AGIO), a leader in cellular metabolism and pyruvate kinase (PK) activation pioneering therapies for rare diseases, today announced the appointment of Jay Backstrom ...