Our brain requires a constant supply of energy. A disrupted energy supply, as, for instance, caused by a stroke, can have ...

Revealing the fundamental principles of how neural circuits are organized and operate is a key challenge in neuroscience. In the past 60 years, intensive effort has been invested in characterizing ...

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A new study shows that when energy is depleted—such as during a stroke—neurons begin releasing glutamate in abnormal, self-amplifying bursts that can damage nerve cells.

Beta-synuclein is a protein found in the brain, particularly in synapses, where it plays a role in regulating neurotransmitter release. In Alzheimer’s disease, synaptic degradation causes ...

A fluorescent probe designed to incorporate a fluorophore into the structure of a neurotransmitter finds activity-dependent heterogeneity in dopamine release at individual synapses ...

Alcohol has been reported to enhance GABA (gamma amino butyric acid, an inhibitory neurotransmitter) release and act directly at GABA receptors as mechanisms by which alcohol causes relaxation.

This suggests that incorporating functional porosomes into neurons affected by AD could potentially restore neurotransmitter release, communication, and plasticity—critical components for ...