A biopsy was performed on the new lesion 16 hours after the onset of the eruption. Histopathology revealed an intact epidermis with intraepidermal collections of neutrophils, serum, and eosinophils.

The lymphocytic infiltrate can spread into the epidermis where there are erythrocytes, necrotic keratinocytes, neutrophilic inclusions, spongiosis, vascular degeneration with intra-epidermal ...

Renewal of the epidermis relies on stem cells located in its lowest layer, which constantly produce new keratinocytes. These new cells are then pushed to the surface, differentiating along the way ...

“The epidermis consists of keratinized stratified squamous epithelium, which is primarily comprised of keratinocytes,” said the study’s corresponding author, Masayuki Amagai.

Keratinocytes of the Upper Epidermis and Isthmus of Hair Follicles Express Hemoglobin mRNA and Protein. Journal of Investigative Dermatology, 2023; 143 (12): 2346 DOI: 10.1016/j.jid.2023.08.008 ...

Researchers discovered the hemoglobin α protein in keratinocytes of the epidermis and in hair follicles. This unexpected evidence adds a new facet to the understanding of the workings of our skin ...

The first objective of the team was to obtain skin stem cells (keratinocytes) similar to those naturally present in the human epidermis from hES cells. Keratinocytes, permit the constant renewal ...

The epidermis of psoriasis patients is also known to produce high levels of hepcidin, which is thought to attract neutrophils to fight infections. However, the exact role of this hormonal peptide ...

Further in vitro work then confirmed these hESC-derived keratinocytes could generate a functional epidermis in vitro. The resulting tissue demonstrated all the features, including self-renewal ...