Chinese researchers have identified key immune checkpoints on natural killer (NK) cells that enable tumors to evade immune ...

On the one hand, this state is contributed by context-dependent interactions between inhibitory NK cell checkpoint receptors and their ligands, which usually vary in different tumor types and ...

CIS, a negative regulator of IL-15 signaling, is upregulated by IL-15 in NK cells, and its absence enhances NK cell sensitivity to IL-15, proliferation, survival, and cytotoxicity against tumor cells.

Research has discovered that the activity of NK cells can be selectively switched on and off via the use of their cell-surface inhibitory receptors such as NKG2A, T cell immunoglobulin, and mucin ...