Medications that promote repair of the myelin sheath that protects nerve cells may help limit damage due to MS, a trial ...

The laminin-411 protein is vital for the formation of the myelin membrane by oligodendrocytes, report researchers from Japan. Furthermore, the A4G47 peptide from the E8 region of laminin-411 was found ...

"Myelin requires a lot of lipids [a group of molecules that includes fats] for normal function," Grutzendler says. "In Alzheimer's disease, lipid metabolism could be abnormally affected in a way ...

Journal Reference: Franziska Auer, Stavros Vagionitis, Tim Czopka. Evidence for Myelin Sheath Remodeling in the CNS Revealed by In Vivo Imaging. Current Biology, 2018; DOI: 10.1016/j.cub.2018.01.017 ...

A study published on November 16 in Nature suggests that one way APOE4 may contribute to Alzheimer’s disease is by causing cholesterol to accumulate inside oligodendrocytes, reducing the cells’ ...

27 Aug 2021 As the brain ages, the insulating myelin sheath around axons begins to degrade. Could this white-matter degeneration trigger Alzheimer’s disease? In a preprint on bioRxiv, researchers led ...

In this imaging study, brain regions with higher levels of myelin showed lower levels of tau protein deposition, and regions connected by myelin-rich fiber tracts showed reduced spreading of tau ...

Not all multiple sclerosis-like diseases are alike Date: May 19, 2020 Source: Tohoku University Summary: Scientists say some myelin-damaging disorders have a distinctive pathology that groups them ...

Review Article Published: 05 January 2018 Adulthood leukodystrophies Wolfgang Köhler, Julian Curiel & Adeline Vanderver Nature Reviews Neurology 14, 94–105 (2018) Cite this article ...

Researchers have demonstrated that enhancing myelin renewal in the brains of transgenic APP/PS1 mouse models of Alzheimer's disease (AD) can improve their task-related hippocampal activity. "To the ...

Brain injuries can also cause damage to myelin. Finding a way to help the sheath to repair itself could open the door to game-changing treatments for these conditions.