Inosine, a substance released by cells in response to metabolic stress, helped rhesus monkeys regain motor function after a brain injury, researchers report.

Inosine can also be introduced into RNA through a process called A-to-I RNA editing. In this process, adenosine deaminases acting on RNA (ADARs) convert adenosine (A) to inosine (I) by hydrolytic ...

In already obese mice, injection of inosine for 26 days significantly lowered the animals’ bodyweight as a result of reduced fat mass compared with control mice from Day 7 onward, the team reported.

Inosine enhances recovery of grasp following cortical injury to the primary motor cortex of the rhesus monkey. Restorative Neurology and Neuroscience, 2016; 1 DOI: 10.3233/RNN-160661 ...

In the inosine groups, serum urate rose by 2.3 and 3.0 mg/dL (P< 0.001 for each) compared to placebo. Cerebrospinal fluid urate levels were also significantly greater in both inosine groups (P =0. ...

"Inosine treatment safely elevates urate levels in Parkinson's disease patients." ScienceDaily. ScienceDaily, 23 December 2013. <www.sciencedaily.com / releases / 2013 / 12 / 131223181418.htm>.

The drug inosine appears to be a safe and effective way to raise blood and cerebrospinal fluid urate levels in patients with early Parkinson disease, suggesting it may be a potential strategy to ...

Domingo M. Aviado, Effects of Fluorocarbons, Chlorinated Solvents, and Inosine on the Cardiopulmonary System, Environmental Health Perspectives, Vol. 26 (Oct., 1978 ...

The paper S.C. Kim et al., “Inosine, but none of the 8-oxo-purines, is a plausible component of a primordial version of RNA,” PNAS, 115:13318–23, 2018. Proponents of the RNA world theory argue that ...

More information: Tara L. Moore et al, Inosine enhances recovery of grasp following cortical injury to the primary motor cortex of the rhesus monkey, Restorative Neurology and Neuroscience (2016).