The “I’m in Danger” meme, featuring Ralph Wiggum from “The Simpsons,” stands out for its widespread appeal in the vast landscape of internet memes. Its journey from a line in a crossover ...

According to Know Your Meme, the preeminent source, the first use of "I'm in danger" was posted on Reddit by FlimFlambadam in March 2018. It's a reasonably on-the-nose gag.