The fatty acid biosynthetic factory is an important target in the fight against this infectious bacterium. The fatty acid synthase (FAS) is considered one of the most complex cellular machines.

Shuttle through the fatty acid factory In yeast, the FAS has the shape of a barrel and consists of two domes with a total of six reaction chambers. Just like its human counterpart, it forms fatty ...

Sagimet Biosciences Announces Completion of Patient Enrollment in Phase 2b ‘FASCINATE-2’ Clinical Trial with Denifanstat (TVB-2640), a First-in-Class Fatty Acid Synthase Inhibitor, in Non ...

Fatty-acid synthase (FASN), selectively overexpressed in prostate cancer (PCa) cells, has been described as linked to the aggressiveness of PCa. Constitutional genetic variation of the FASN gene ...

Mammalian fatty acid synthase is a multifunctional enzyme complex involved in de novo synthesis of saturated fatty acids, and inhibitors of fatty acid synthase are being evaluated as potential ...

Zhonglin Mou, Yikun He, Ya Dai, Xinfang Liu, Jiayang Li, Deficiency in Fatty Acid Synthase Leads to Premature Cell Death and Dramatic Alterations in Plant Morphology, The Plant Cell, Vol. 12, No. 3 ...

TVB-2640, a fatty acid synthase inhibitor, significantly reduced liver fat and serum biomarkers of liver injury, fibrosis and inflammation in patients with nonalcoholic steatohepatitis according ...

In tumor cells, most fatty acids are synthesized de novo by fatty acid synthase (FASN) to meet the excessive bioenergetic and structural demands of proliferation. 1 FASN is overexpressed in prostate ...