Researchers have systematically mapped the complex cellular pathways leading to glucocorticoid-induced osteonecrosis of the ...

The extrinsic pathway of mammalian PCD Death receptors constitute a TNF receptor superfamily. The prototypical death receptor is Fas (CD95), and Fas-mediated apoptosis will serve as an ...

Mechanisms of Apoptotic Cell Death Apoptosis is a tightly controlled mechanism of cellular suicide that is crucial to remove unwanted cells from the body, as first described by Kerr et al. in 1972 ...

The extrinsic pathway, also known as the death receptor pathway, causes apoptosis when extracellular ligands bind cognate transmembrane death receptors. This event triggers a downstream caspase ...

It was less effective, however, in cell lines without BCL6. Further analysis showed that TCIP1 targets multiple death pathways including popular ones like TNF signaling and the p53 pathway.

Youtong Huang, Greg Lemke, Early death in a mouse model of Alzheimer’s disease exacerbated by microglial loss of TAM receptor signaling, Proceedings of the National Academy of Sciences of the United ...