The discovery of restriction enzymes began with a hypothesis. In the 1960s, Werner Arber observed a dramatic change in the bacteriophage DNA after it invaded these resistant strains of bacteria ...

“In the early days, you couldn’t do much with DNA because it was a very large molecule,” Roberts recalled. “As soon as the Type II restriction enzymes were discovered—and HindII in particular—it was ...

DNA is often seen as the blueprint of life—carrying the code to govern the development and traits of an organism—but “there ...

A few years ago, the advent of technology known as CRISPR was a major breakthrough in the scientific world. Developed from a ...

The cutting and joining manipulations that underlies gene cloning are carried out by enzymes called restriction endonucleases (for cutting) and ligases (for joining). Nucleases degrade DNA molecules ...

Various types of endonucleases – enzymes that can cut DNA – were already known before CRISPR-Cas9. The discovery of restriction enzymes in the early 1970s heralded a new age in molecular biology.

The goal of my research is to understand the mechanisms and structures of enzymes that perform and regulate essential nucleic acid transactions. My research integrates diverse experimental approaches ...

Restriction enzymes are one of the most important tools in the recombinant DNA technology toolbox. But how were these enzymes discovered? And what makes them so useful? Aa Aa Aa When I come to the ...