Journal References: Zuanning Yuan, Roxana Georgescu, Nina Y. Yao, Olga Yurieva, Michael E. O’Donnell, Huilin Li. Mechanism of PCNA loading by Ctf18-RFC for leading-strand DNA synthesis. Science ...

On their own, however, polymerases aren’t good at staying on the DNA strand. They require CTF18-RFC in humans and Ctf18-RFC in yeast to thread a ring-shaped clamp onto the DNA leading strand ...

DNA replication is a fundamental biological process that enables the accurate duplication of an organism’s genetic material. This intricate mechanism ensures that each new cell receives a complete set ...

Their findings, published recently in Nature, demonstrated that while telomerase addressed the end-replication problem at the leading strand, another complex worked in tandem at the lagging strand. 3 ...

Technology DNA nanobots can exponentially self-replicate Tiny machines made from strands of DNA can build copies of themselves, leading to exponential replication. Similar devices could one day be ...