Hypermethylation of CpG islands can cause tumors by shutting off tumor-suppressor genes. In fact, these types of changes may be more common in human cancer than DNA sequence mutations (Figure 2).

DNA methylation data provide extremely accurate age predictors, but so far, little is known about the dynamics of this epigenomic biomarker over the course of life. A team of researchers from the ...

These modifications, which include DNA methylation ... For instance, abnormal CpG island hypermethylation is frequently observed in cancers and is often linked to tumor suppressor genes.