If you’re attached to that favorite DB-9 interfaced device you should look into this part. FTDI is selling a USB-RS232 adapter as a replacement for DB-9 connectors. They come with USB male or… ...

No it isn't possible. RS232 serial is a very simple protocol and USB is relatively complicated. I've had success with the Keyspan USB-serial adapters, even on Macs and 64-bit Windows if that helps.