Cytosine has the chemical formula C 4 H 5 N 3 O and a molar mass of 111.10 g/mol. It is a weakly basic compound due to the presence of the primary amine group. The heterocyclic aromatic ring of ...

One method cells use to modulate the level of a gene's expression is chemically attaching a methyl group (-CH3) to cytosine residues in the DNA of a gene or in the regulatory regions surrounding it.

After treatment with sodium bisulfite, unmethylated cytosine residues become uracil residues, which are recognized as thymine after PCR amplification and sequencing analysis. Researchers determine ...

The hydrolytic deamination of cytosine and 5-methylcytosine residues in DNA appears to contribute significantly to the appearance of spontaneous mutations in microorganisms and in human disease. In ...

The replacement of Tyr 34, a residue participating in a hydrogen bond with 5-methyl cytosine, with phenylalanine in mouse MBD3 provides a structural explanation for its lack of selectivity.

25 Jun 2010 One of the best-studied epigenetic modifications, methylation is the addition of a methyl group to a cytosine residue of DNA, usually at a cytosine paired to a guanine (CpG site).

In mammalian cells DNA methylation occurs at cytosine residues of cytosine-phosphate-guanine (CpG) sequences, which leads to repression of gene expression.

DNA methylation involves the addition of a methyl group (-CH 3) to cytosine residues within DNA. Typically, only cytosine residues adjacent to guanine are methylated, and such pairs are identified as ...

RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia. Nature Communications, 2018; 9 (1) DOI: 10.1038/s41467-018 ...

Posttranscriptional methylation of RNA cytosine residues to 5-methylcytosine (m5C) is an important modification with diverse roles, such as regulating stress responses, stem cell proliferation, and ...