Cytidine deaminase inhibitors (CDA): Pipeline Development Activities The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage.

Furthermore, cytidine’s efficacy in bipolar depression may be mediated by decreased levels of cerebral glutamate and/or glutamine, consistent with alterations in excitatory neurotransmission.

Gemcitabine is an antimetabolite drug used in the treatment of various solid tumors in adults, including pancreatic and lung cancers, and it can be considered as an attractive therapeutic option in ...

These findings establish a role for cytidine nucleotides in photoreceptor cell metabolism and in light-dependent increases in RNA and PI synthesis. Furthermore, the observations indicate that a ...

Arne Bøyum, Vivi-Ann Tennfjord, Christine Gran, Dagfinn Løvhaug, Olav Øktedalen, Petter Brandtzaeg, Bioactive Cytidine Deaminase, an Inhibitor of Granulocyte-Macrophage Colony-Forming Cells, Is ...

We now recognize that deregulated expression of activation-induced cytidine deaminase within germinal-center B cells leads to MYC chromosomal translocations. Plasmodium infections in mouse models ...

A simple test to evaluate CDA phenotypic status was first validated in an animal model investigating relationships between CDA activity and gemcitabine-related toxicities. Next, relevance of this test ...