Awad concluded, “Overall, our study reveals that components of cigarette smoke can bind to the protein MR1 and reduce the functions of protective immune cells called MAIT cells.

More information: Wael Awad et al, Cigarette smoke components modulate the MR1-MAIT axis, Journal of Experimental Medicine (2024). DOI: 10.1084/jem.20240896 Provided by Monash University ...

This illustration explores how smoke components in cigarette and e-cigarette smoke obscures critical molecules like Smole-binding ligands and MR1 complexes, disrupting T cell responses ...

Chronic e-cigarette use impairs endothelial function on the physiological and cellular levels. Arteriosclerosis, Thrombosis, and Vascular Biology. DOI: 10.1161/ATVBAHA.121.317749 Impairment of ...

Light cigarettes, as well as new slow-burning and other "safer" varieties that claim to reduce health risks, may be just as harmful as conventional cigarettes, according to a major report released ...

The researchers now plan to investigate exactly which MAIT cell pathways are impacted by cigarette smoke, in order to learn how to better treat COPD and other lung diseases. Reference: Awad W, Mayall ...

E-cigarettes contain the highly addictive substance nicotine. Credit: Liudmila Chernetska/ Getty Images After a few vigorous puffs of a burning cigarette, a smoker’s lungs will be filled with a ...

Researchers say e-cigarettes and tobacco cigarettes have similar negative health effects on a person’s cardiovascular system. They add that smoking and vaping at the same time have even serious ...

Prolonged exposure to cigarette smoke destroys the air sacs in mouse lungs (left). But this destruction is prevented in mice lacking MAIT cells (right). Cigarette smoking is widespread and deadly ...