2006), as discussed later in this article. Chromatin structure is highly complex and impressively dynamic. Scientists now realize that the nucleosome, which was once thought to be static ...

Most cells in the human body each contain about six feet of DNA. Yet the nucleus, where DNA is coiled, is no larger than a ...

The proper folding of the chromatin structure plays a crucial role in the regulation of genomic DNA functions, its disruption leading to various diseases. Therefore, understanding the chromatin ...

Scientists at St. Jude Children’s Research Hospital used a series of cryo-EM structures to visualize dynamics pivotal to chromatin remodeling, a process implicated in cancer and developmental ...

As previously mentioned, chromatin is remodeled (and thus, nucleosome structure is altered) primarily through posttranslational modifications of histone proteins, which actually change the ...

Varshavsky studied chromatin structure and wanted to develop new methods to detect the DNA-protein interplay in intact cells. Motivated to better understand chromatin structural organization, ...

Numerous widely used chemicals induce genetic and epigenetic alterations implicated in various diseases, including cancer.

Genes lacking a particular structure known as CpG islands tend to go haywire in older cells, a study finds, potentially contributing to key facets of aging. But it’s not yet clear if the relationship ...

Now, for the first time, EMBL scientists have directly observed this process in high resolution under the microscope using a new chromatin tracing method. The new study shows that the long DNA ...