The activity and sterility of reconstituted alteplase solution and the effectiveness of an alteplase dose-escalation protocol for the clearance of midlinecatheter and central-venous-access device ...

Extending the treatment window for intravenous thrombolysis beyond 4.5 hours may benefit patients with posterior circulation ischemic stroke. New research findings are summarized in a short video.

For patients with mainly mild posterior circulation ischemic stroke, alteplase administered at 4.5 to 24 hours after onset results in higher frequency of functional independence.

Intravenous alteplase (recombinant tissue plasminogen activator) is restricted for use within 3 h from stroke onset by marketing authorizations. Some patients are treated beyond this approved time ...

Alteplase 0.5, 1, and 2 mg/mL retained maximum fibrinolytic activity when stored for no more than 48 hours at 2 °C, regardless of initial storage at -70 or -25 °C. An alteplase dose-escalation ...

Researchers found that the percentage of patients with functional independence at 90 days was higher in the alteplase group vs the standard treatment group. HealthDay News — For patients with ...