Background Regular intensive physical activity is associated with non-pathological changes in cardiac morphology. Differential diagnosis with arrhythmogenic right ventricular cardiomyopathy (ARVC) ...

The genetic disease ARVC leads to sudden cardiac death and is more common than it has been hitherto assumed. An international research team revealed that all families who are known to be affected ...

More information: Ronny Schweitzer et al, Establishing Cardiac MRI Reference Ranges Stratified by Sex and Age for Cardiovascular Function during Exercise, Radiology: Cardiothoracic Imaging (2025).

The TMEM43 Newfoundland mutation p.S358L causing ARVC-5 was imported from Europe and increases the stiffness of the cell nucleus. European Heart Journal, 2014; DOI: 10.1093/eurheartj/ehu077 ...

ARVC affects between 1 in 1,000 and 1 in 1,250 people and is a leading cause of sudden death among young athletes who have no prior symptoms or cardiovascular disease diagnosis.

The ARVC heart cells contract irregularly, whereas the heart cells from people who don't have the variant beat regularly. The long-term goal is even more ambitious.

RIDGE is Largest Natural History Study Conducted with More Than 175 Participants Enrolled to Date with Arrhythmogenic Right Ventricular Cardiomyopathy Due to Mutations in the PKP2 Gene Patients ...

The interim data from RIDGE will be presented at Heart Rhythm 2025 on April 26, 2025 by Dr. Calkins during the Basic Translational Science session in a poster titled " Determining Eligibility for ...