DNA and histone methylation coregulate heterochromatin formation and gene silencing in animals and plants. To identify factors involved in maintaining gene silencing, we conducted a forward genetic ...

Epigenetics, the mechanisms that control gene expression via modifications made to DNA, operate through two key approaches in eukaryotes. The first, histone modification, involves the modification of ...

Histone-based predictors were compared to DNA methylation-based predictors, with the study noting the impact of differences in sample size and dataset distributions on the comparison.

Mechanisms of action and resistance in histone methylation-targeted therapy. Nature, 2024; DOI: 10.1038/s41586-024-07103-x ...

Kezhi Zheng, Lili Wang, Longjun Zeng, Dachao Xu, Zhongxin Guo, Xiquan Gao, Dong-Lei Yang, The effect of RNA polymerase V on 24-nt siRNA accumulation depends on DNA methylation contexts and histone ...

In males, a protein called KDM3A is responsible for removing this histone methylation, allowing the Sry gene to become active. We already knew that KDM3A requires iron for its enzymatic activity.

Discover how histone modifications unlock secrets of human aging, rivaling the precision of DNA methylation in decoding biological age. In a recent study published in the journal Science Advances ...