Mapping the Genome’s 3D Structure The research team discovered that the genome arranges itself into two distinct compartments: one active and accessible, the other more tightly packed and inactive.

Investigating chromatin's 3D architecture reveals its influence on gene regulation, shedding light on mechanisms underlying cancer and muscular dystrophy.

Synergies in breast cancer cells were associated with tyfonas, a class of complex DNA amplicons. These results rigorously link genome-wide high-order 3D interactions to lineage-defining ...

While it can be helpful for learners to begin with the linear presentation of how stretches of DNA form genes, this oversimplification undersells the significance of the genome's 3D structure.

"Artificial intelligence tools predict DNA's regulatory role and 3D structure." ScienceDaily. ScienceDaily, 8 August 2022. <www.sciencedaily.com / releases / 2022 / 08 / 220808162100.htm>.

Two new landmark studies show how a seeming tangle of DNA is actually organized into a structure that coordinates thousands of genes to form a sperm cell. The work, published March 3 as two papers in ...