The Jacksonville Jaguars (4-12) are 4.5-point underdogs in a road AFC South matchup against the Indianapolis Colts (7-9) on Sunday, January 5, 2025 at Lucas Oil Stadium.NFL odds courtesy of BetMGM

As it stands, Jacksonville holds 10 picks in the 2025 NFL Draft. They’re slated to pick once in the first round, once in the second round, twice in the third and fourth round, once in the fifth round, twice in the sixth round and once in the seventh round.

Strangely, vibes are much better on the sidelines of the 4-12 team than the one at 7-9. While a loss is better for the Jaguars' chances at getting a top-five pick — even the first pick is still an outside shot — they are not playing with that mentality. Even if the Colts sneak out a victory here, it will not be by more than five points.

The Indianapolis Colts and Jacksonville Jaguars complete disappointing seasons at Lucas Oil Stadium. Who ya got?

NFL Week 18 odds, picks, predictions, TV channel, streaming information for Sunday football game between Jacksonville Jaguars and Indianapolis Colts.

Jacksonville’s third win of the 2022 season, 26-11 in the season finale, knocked the Colts out of the playoffs

Preview the Week 18 matchup between the Indianapolis Colts and Jacksonville Jaguars with predictions, odds, over/under, spread, betting lines and more.

With the Indianapolis Colts now officially out of playoff contention following last week’s “embarrassing” performance against the New York Giants, let’s take a look ahead to the 2025 NFL draft and where they are currently selecting.